Sickle Cell Anemia
We will discuss what causes sickle cell anemia, what the symptoms are, what is done to treat this disease, and tests available.
CAUSES
It's inherited. The inherited gene causes the body to make abnormal hemoglobin "S." Normal hgb is "A." One inherited gene will cause Sickle Cell Trait which can be passed on to the next generation. Two genes will cause Sickle Cell Disease. The disease is present at birth, but babies usually don't show symptoms until about four months old. The abnormal hemoglobin (hgb) causes the red blood cells to be crescent shaped, like a sickle. Normal red cells are doughnut shaped. These sickle shaped red blood cells clump together and get caught in blood vessels. The abnormal hemoglobin (hgb) causes anemia. Hemoglobin is made of protein and iron. Hgb "S" does not have as much iron as normal hgb.
SYMPTOMS
The most common symptom is sudden pain. This is due to the abnormal red cells getting caught in the blood vessels in the limbs and organs. Fatigue. This is due to the anemia. Chest pain. This is caused by the cells getting trapped in the lungs, or an infection. Dizziness Headache Cold hands and feet Infections. These are due to the spleen being damaged. Your spleen helps to fight infections.
TESTS
A red cell analysis(CBC or ABC), including studying the cells under a microscope, will show the shape of the cells. The "Sickle Cell Test" determines if abnormal hgb is present in the blood. A deoxygenating agent is added to the blood. A technologist examines the sample under the microscope to look for sickled cells. This shows if the patient has either the trait or the disease. Hemoglobin electrophoresis determines the type of hgb by passing an electric charge through a solution of the patient's blood. Different hgb's travel different distances.
TREATMENT
Pain management IV fluids. It's important for the patient to drink lots of fluids to help prevent a sickle cell crisis. Antibiotics for infection Vaccination against pneumonia Blood transfusion Medication to prevent a painful crisis. There are possible serious side effects to the medication, however. Possible bone marrow transplant
Carriers of the trait may choose to consult a genetic counselor. Scientists are currently researching gene therapy. They're also searching for new medicines, with hope that their research will provide better treatment for this disease.
Anemia Treatment – How to Treat Anemia From Home
The treatment of anemia is dependent on type of anemia that you have. If the cause of anemia is by internal bleeding or cancer then a more serious treatment may be required such as surgery.
Anemia can be caused by a wide variety of environmental triggers such as chemotherapy or heavy metal exposure.
Internal bleeding caused by hemorrhoids is also a common cause that patients are unaware of.
Very often though Anemia has a behavioural causation (Your actions have caused it)
And once the source problem is known it can often be treated by you. The obvious trigger is diet related in which the treatment revolves around a high iron and vitamin rich diet.
The other alternative often prescribed by the doctor is to take 1-2 Iron tablets daily with vitamin C rich food which aids in the uptake of iron.
Iron can be purchased in tablet form from most supermarkets.
If you are interested in getting your anemia from more natural sources try eating more red meat, beans, fish, liver and green vegetables. Try to consume your high iron foods with vitamin C. This helps the absorption of the iron itself.
If you plan to cure your anemia from home then you will need to know a little about it.
Anemia Is a disease of the blood in which either an Iron or vitamin B12 deficiency causes a decreased carrying capacity of oxygen.
A lack of Vitamin b12 usually means a decreased Oxygen carrying efficiency of the hemoglobin. A lack of Iron causes fewer red blood cells to be produced, leading to less oxygen carried by the blood.
In both scenarios one is left feeling weak and often tired from light exercise. This affects your day to day life and decreased work output.
Iron Deficiency – Anemia
Iron is in abundance in nature and in our food, so why is iron deficiency anemia as common as it is? Is everyone who has low iron levels diagnosed with Anemia? How is iron deficiency determined? How do I know if I'm getting enough? First we need to gain some basic understanding about iron and how we can become deficient.
What does the body use iron for?
Iron is most commonly known for it's essential role in the formation of hemoglobin, the substance in the red blood cells that carry oxygen. Hemoglobin is a complex molecule with iron in the center and is identical to chlorophyll in green plants except the iron is replaced with magnesium. Iron is also needed for cells to use oxygen to produce energy to function. This vital mineral is also needed for the immune system; deficiency makes neutrophils (one type of white blood cell) less effective. It is also needed to enable your brain to work properly. Another interesting role iron plays is in the detoxification of drugs and other toxins taken into the body.
What causes iron deficiency?
There is no particular elimination mechanism in the body for iron. It is mostly lost in bleeding, such as during menstruation and major injury, with a small loss from sweat, hair and dead skin cells flaking off and in the bile. What the body does is control the amount coming in, and 90% of iron is recovered and recycled. Recycling not an idea originated by man, but his creator. If the body needs iron it absorbs more, if it has enough it will stop absorbing it. Most people's diet is abundant in iron. Deficiency usually comes from poor absorption, rather than from lack in the diet, although anemia can result from blood loss, and occult (hidden) blood loss such as hook worm infestation and bleeding ulcers. While iron in animal products (mainly from the blood consumed) is absorbed more readily, animal products require iron and other nutrients to detoxify the toxins they contain. About of 5 to 10% of the iron in food is normally absorbed. This can go up in times of extra demand such as menstruation and in cases of anemia when it can be as high as 45 to 64%.
The major cause of iron deficiency is vitamin C deficiency as well as anti iron substances in our western diet. Such as Tea and coffee which reduce absorption. Vitamin C is easily destroyed. An orange can lose most of it's vitamin C within hours of picking. Processing destroys many vitamins, including up to 90% of vitamin C and most people's diet is grossly deficient in fresh fruits and vegetable which are high in vitamin C. Vitamin C is essential for the absorption of iron. The digestive function is critical, low stomach acid, antacids can reduce absorption. Lack of intrinsic factor in the stomach prevents absorption. This intrinsic factor is similar in structure to B12's intrinsic factor, and heme, the iron containing molecule in hemoglobin.
It is interesting to note that chlorophyll in green leafy vegetables have a similar in structure. Both heme and chlorophyll have the same structure, except that heme has iron in the center, chlorophyll has magnesium. Oxalates and phytates in food bind to iron but calcium causes it to be released. Again it is interesting that calcium is high in green leafy vegetables, especially Chinese greens. It seems to me that this is no accident! Iron must be chelated (bound) to be transported. Unbound inorganic iron feeds certain bacteria. Lack of phytate to bind free iron has been implicated in colon cancer. Phytic acid, also called phytate, is known as Inositol Hexaphosphate (IP6) (Inositol is a member of the B group of vitamins). This interesting substance binds to minerals. It has been thought that it prevents their proper absorption. This assumption has been shown to be incorrect. It does bind minerals in order to transport them and it appears that it releases them when needed.
Free, inorganic iron is toxic.
Iron will react very readily with oxygen causing substances which destroy cell membranes, including that of the gastrointestinal tract. Excess can cause a number of iron overload diseases. It can cause irritation to mucus membranes and bleeding, liver damage and renal failure. Many bacteria also need iron and unbound iron can cause bacteria to multiply. Overload has occurred in South African Natives from alcohol distilled in iron stills and cooking in iron cooking pot. This would have been inorganic free iron which would have caused GIT irritation. Too many blood transfusions can also cause Iron overload.
How is iron deficiency determined?
Iron deficiency Anemia is usually diagnosed by a blood test and looking at symptoms.
Pathology Blood Tests. A Hemoglobin count is taken from a blood sample and if the count is below a set lower limit, the person is considered to have iron deficiency anemia, if above a set upper limit, the person is considered to have an excess or iron overload. Symptoms are also considered of course. Now Pathology blood tests can provide very valuable information, however like any test done on anything it needs to be properly interpreted. The limitation is that all the test can tell anyone is what is happening in the blood at the instant the sample was taken. Also it tells what is in the blood, not the tissues. The blood can also be high in a mineral because it is bringing out from one place to transport it to another. In one case a lady had dangerously low Hemoglobin in her first test and before her second test, which showed normal iron levels, she had eaten a meal mainly of whole grains and used a lot of vitamin C. I must emphasis at this point that pathology blood test and Naturopathic blood test are looking at different sides of the picture. I have had people show low B12 in my live blood test when there Pathology Blood test showed normal B12. There was enough B12 in their blood at the time, but the overall average was low. A Naturopathic blood test is looking at the deficiency by how the blood cells were formed giving a long term picture, Pathology blood tests are looking at what is happening in the moment.
Deficiency Symptoms
Fatigue, decreased exercise tolerance, behavioral changes, anorexia, and pica (compulsive eating of non-food items), cognitive and growth abnormalities in children, pale skin, inside lower eyelid, finger and toenails and gums, fingernails can be thin and spoon shaped; burning and red mouth and tongue; smooth, waxy, glistening tongue and gastritis. Please note, other factors besides iron deficiency can cause these symptoms. See a health care professional such as a Naturopath for confirmation.
How do I ensure I'm getting enough iron?
I consider the best supplement for iron deficiency is vitamin C combined with a diet high in iron rich foods such as parsley, pine nuts, legumes especially soybeans, sunflower and pumpkin seeds, whole grains and green leafy vegetables, especially Chinese vegetables. Vitamin C must be taken with bioflavonoids, vitamin E, and Beta Carotene otherwise it becomes a free radical in it's self and can cause damage. Use plenty of vitamin C rich raw fruit and vegetables such as lemons, citrus, black current, red capsicum, rose hips, parsley, raw cabbage, pineapple etc. Because of modern Horticulture, it is unlikely to be enough. Don't use ironware cookware on a regular basis. If you want to use an iron supplement, use one that is naturally derived, not an iron salt. Many common iron supplements can encourage bacterial growth. They also can cause constipation, so take measures to make certain your bowels are moving regularly, at least twice a day. Mineral deficiencies can be found by a naturopath using live blood analysis.
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lower eyelid as indicative of anemiaRestoring Your Iron Balance With Supplements and Dieting
Iron is one of the most important minerals that our body needs in order to function well. Without the recommended dosage of iron, you can feel tired, irritable, and nausea. With a proper diet and the right supplements, you can be back on your way to restoring your iron deficiency and energy!
Iron is just one of the minerals found in hemoglobin. Hemoglobin carries oxygen through the bloodstream, therefore carrying it throughout the body. Without the right amount of hemoglobin in our system, we can start to feel the effects. Some of us might have constant digestive problems, headaches and built up stress.
Not everyone who is low in iron has anemia but most iron deficient people have what is called anemia. Iron is needed to create the energy our body lives in. Without this, we will most likely feel tired, falsely being compared to chronic fatigue.
Iron deficiency anemia is common among women. Pregnant women, especially in their third trimester, are very likely to become iron deficient. Pregnant women who are either in or entering their third trimester should be more concerned on how much iron is needed making sure it is enough for two!
Being deficient in iron is not the end of the world for most people. It takes a little patience and commitment to restore your iron balance. Some of the most important procedures to restoring your iron levels are taking the right supplements and looking closer at your meal choices.
Iron can be found in a lot of the foods that we eat. The most effective way is to consume foods in which the iron is absorbable. Some of these foods are poultry, fish and meats. Other foods not including "meat" are leafy greens, certain sources of fruit and some sources found in alcohol.
There is another way to get the right amount of iron we need. Iron is found in a lot of supplements and is a partial ingredient to any multi vitamin. Today there are almost too many supplements to choose from.
When targeting a specific area of nutrition, you should carefully look for supplements that will boost what you are missing. In this case, you want to look for something that contains a high source of iron.
One thing I want to stress is too much iron can cause digestive problems. Some of the side effects of having too much iron are; abdominal pain, your stool being dark in color, almost black, constipation and diarrhea with traces of blood in it.
There are a few possibilities in which we can absorb too much iron. If we eat too much meat day after day iron will build up and serious constipation occurs. While certain nutrients are great in abundance, consuming too much iron is not recommended.
Another way to have too much iron in our systems is the misuse of related supplements. As with any supplement, take only as directed. Iron is not a mineral that we can just double up on, unlike other vitamins like vitamin c when we feel a cold coming on. Too much of a good thing does not always work out for the better!
We need the right amount of iron daily. Too little and we might be fatigued and too much can lead to digestive pains and constipation. If you are still unsure of the symptoms of anemia or a less severe case of iron deficiency, please consult your doctor.
Early Signs of Pregnancy and What to Do Next!
First learning that you are only 2 weeks pregnant is the beginning of a long adventure into motherhood that only begins with pregnancy. Each step of the way, there is something new to discover and feels like your experience is unique. Yet, when you share your stories, it seems like so many others can relate with similar experiences.
Early pregnancy affects women in so many different ways. It is probably safe to say that you will begin noticing changes in your body and how things fit sometime around when you are 4 weeks pregnant or into your second month of pregnancy. One of the first things women notice is a missed period. Another sign of early pregnancy can be morning sickness. It's not always obvious though, and can be confused with symptoms of mild illness. The feelings of nausea are not always in the morning either!
Finding out you are pregnant is one of the most exciting times for a new mother-to-be. You will have many mixed feelings about the future and what will happen next. The first priority should be to find a good OB-GYN physician. They will insure you stay healthy throughout your pregnancy which is critical for the health of your baby. The doctor will put you on track with the proper diet and prenatal vitamins too.
Other concerns you will have is calculating a due date for your baby. How do you know if you are 2 weeks pregnant or if you are 4 weeks pregnant? Well, the doctor will know based on how well you kept track of your cycle. Then, you will begin to wonder about choosing the right baby name! This can take months to decide, so take your time. It's an important decision to make.
Experts agree women are interested in learning more about their body and the changes they go through during pregnancy. Many questions they are asked are about pregnancy problems, like anemia, stretch marks, postpartum depression, and serious birth disorders. Most of these problems are never present and only affect a small number of pregnant women. There are many books on these topics and your doctor can help you too.
Whatever advice you choose to take, pregnancy and motherhood are a wonderful new experience and you should enjoy each and every moment! There is lots of expert advice about pregnancy and parenting your baby, so take time to learn all you can!
Us Doctors Under Fire For Anemia Drug Deal
U.S. doctors are currently criticized for being involved in prescribing high-end medicines for anemia in exchange for their clinics' rebates.
According to the New York Times report, hundreds of millions of dollars are pocketed by some American doctors as they prescribe pharmaceutical products to patients even if they don't need them. The drug companies Amgen Inc. and Johnson & Johnson were the two companies named to work in conspiracy with the questionable deals.
But the two companies said that they are not doing anything wrong. All their transactions were made in legal terms. Johnson & Johnson noted that the rebates were given since doctors purchase the products and dispense them in their clinics and this is a legal practice as a reflection of intense competition.
However, some critics are claiming the anemic pills called EPOs may be used by some doctors as prescribed drugs to anemic patients even if they don't need them at all just to get rebates. This exercise, according to them, is a form of bribery that should not be allowed in the medical practice. In 2006, it was reported that Amgen alone released $2.7 million as rebates and this continues to rise at the end of this year.
American medical companies provide anemia drugs to a million patients annually, making these medicines in demand and a source of revenues for major pharmaceutical companies like Amgen and Johnson & Johnson. Both of these companies reached the calculated $10-billion mark for their revenues in 2006.
Aside from bribery issues, patients are worried that these medicines may post some side effects such as stroke and other risks of heart attacks. Because of this, the FDA suggested the two companies to provide additional safety nets and better guidelines on its prescription and use of these anemia drugs.





