Healthy Tips For Better Life

Viagra may Restore Brain Damage due to Liver Failure

Scientists through the ages have been trying to solve the baffling puzzle behind
liver failure leading to brain damage. But a new research using Viagra has come up
with certain revelations that can uncover the whole mystery. Scientists used
laboratory rats to come up with this interesting medical discovery.

The study, involving rats, has shown that Sildenafil in Viagra can help in
understanding the mechanism responsible for learning impairment due to liver failure
and restore the cognitive function of the brain too. Liver disease sometimes causes
hepatic encephalopathy that results in brain damage, personality changes and
intellectual impairment due to hyperammonemia (high levels of ammonia in the blood).

A study at the Laboratory of Neurobiology in The Fundacion Valenciana de Investigaciones
Biomedicas in Valencia, Spain, led by Vicento Felipo postulated that a defect in the
(glutamate- nitric oxide-cGMP) pathway in the brain cause impaired learning. The study
also found that Sildenafil(Viagra) can restore the learning ability.

The research used laboratoty rats with liver disease that are fed on a normal diet with
and without Sildenafil. The rats were given a maze learning test for four weeks from
the day the drug treatment began. The results demostrated that rats with portacaval shunt
had learning impairment, while shunted rats that were given Sildenafil restored their
cognitive power. The tests further displayed that the concentration of cGMP was
lessened in the extracellular fluid in the brains of shunted rats as compared to the
cGMP concentration in rats that were given Sildenafil. Sildenafil restored levels of
cGMP in these animals.

Rats with portacaval anastomosis (shunts) and rats with hyperammonemia without liver
failure show conformity in the functions of the (glutamate-nitric oxide- cGMP) pathway,
extracellular cGMP and learning ability. It is a clear indication that hyperammonemia,
the only common alteration in both models,is responsible for the alteration of the
pathway's function. It proves that hyperammonemia is responsible for impairment of
learning ability. And Viagra can help you restore the cognitive function.

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